It's definitely happened more than a handful of times. I am drawing a blank on examples but it's happened multiple times in the last maybe 10 years (1 rematch that is) NFL Network said last night it has happened 9 times and the team that won the final week matchup is 4-5 the following week. I remember one year that the Colts lost big to the Broncos in week 17 (the usual Peyton Manning one-series-and-done), then turned around and beat the Broncos (and I don't think it was even close) the next week in the playoffs. 2003 Week 16: Broncos 31, Colts 17 (full participation). 2003-04 Wild Card Game: Colts 41, Broncos 10. 2004 Week 17: Broncos 33, Colts 14 (with Manning, et al, resting). 2004-05 Wild Card Game: Colts 49, Broncos 24. I was thinking of 2004-05. The previous year wasn't back-to-back weeks since they played in week 16, not 17.