It might make good sense to trade down with one of those picks. There will still be lots of really good players in the middle of the 1st round, so a team might make a really good offer for one of those picks. Then you get the 10-20 talent level player with one pick and still have 2-3 more decent picks extra. Depends on what is offered obviously but I'm not opposed to picking up a 2nd and 3rd for one of the 1st rders. I'm happy enough with these positions that I wouldn't want to use a 1st rd pick on: RB, QB, WR, C, TE, OLB, ILB and DT. That leaves G, OT, DE, CB and S. Of those positions DE would be the lowest on my list because Justin Smith is perhaps the best 3-4 DE in the league and Ray McDonald has shown promise. After that I would say go by what falls to you.