Losing Clark is a huge blow (though it was pretty obvious he'd be out for the year from the comments made by the Colts). He's integral to the offense; and, in the past, has often been considered the third most important player on the team. The injuries are disconcertingly piling up. Now, attempting to be optimistic, the injuries have occured at positions the Colts have a little more depth (in my opinion). By no means is this to say the replacements are equal to the starters, but the only one I would consider replacement-level, strong safety Aaron Francisco, has actually played competently the last two weeks. At tight end, Brody Eldridge has been real solid as a blocker, but is not much as a receiver. Jacob Tamme will be asked to fill the pass-receiving threat at tight end. I actually really like him. He was a fourth round pick and has excellent receiving skills. He has not had an opportunity to show it -- having Clark ahead of you is quite the hurdle -- but he may surprise some people. He has played well in the preseason, for what that's worth. Austin Collie is probably my favorite receiver on the team, but they still have Reggie Wayne, Pierre Garcon, and Anthony Gonzalez. Most teams would love to have that triumverate. At running back, Joseph Addai has been really great this year, but the Colts have Donald Brown (former No. 1 draft pick) and Mike Hart (who has played well). I'm far more concerned about picking up the blitz and blocking from those two than I am their running. The depth is being seriously tested and more injuries at those positions could be devastating. But, assuming Gonzalez and Brown can stay healthy (something they haven't proven capable of so far), the Colts could persist relatively well.