Isringhausen actually had a darn good season in 2005, posting his career best save ratio and career best ERA. What stands out the most in 2006 is the dramatic increase in walks and consequently in WHIP. The lack of control would seem to indicate that there may be some physically wrong. While his ERA was good last year, he had his worst K/BB, K/9 and BB/9 ratios since coming to the Cardinals. But, it's possible that he's not fully healthy. His P/PA is way up to 4.2 after being around 3.7-3.8 consistently in the past, and as you noted his walk rate is way up. He's also has his smallest G/F ratio since coming to the Cards... so not only is he more wild but he's leaving the ball up. His OPS against is .704, and it has never been above .581 as a Cardinal.