Greinke and Verlander have a chance if they pitch another couple of years, but he might be the last pitcher we see pass 3,500 innings in a long time. Curiosity struck, and I was actually somewhat shocked how similar Zambrano and Sabathia were from 03-09, when both were ages 22-28.
Zambrano: 1435 IP, 3.44 ERA, 131 ERA+, 1.278 WHIP, 7.7 K/9, 33.6 bWAR (walks were the big outlier)
Sabathia: 1499 IP, 3.42 ERA, 129 ERA+, 1.200 WHIP, 7.6 K/9, 32.4 bWAR