I wouldn't suggest it. That takes about an hour and forty-five minutes. You want to take the Blue Line to the Addison stop, get on the Addison 152 CTA bus, and ride that to Wrigley. Yup...or possibly Skokie/Evanston area and taking skokie swift (yellow) or purple and transferring to red and getting off at Addison. Regardless, I'd suggest finding a nearby suburb to stay in and taking a train to the game. Downtown prices are ridiculous right now. Skokie Swift doesn't run on weekends.